Replication competent adenoviral platform for in situ production of immunotherapeutic RNA aptamers targeting 4 1BB
Antonio Tallón, Virginia Laspidea, Iker Ausejo‐Mauleon, Daniel de la Nava, Sara Labiano, Marisol González-Huarriz, Marta Zalacaín, Ana Patiño‐García, Helena Villanueva, Juan Fueyo-Margareto, Candelaria Gomez‐Manzano, Ignacio Melero, Fernando Pastor, Marta M. Alonso, Marc Garcia Moure
This paper develops a replication-competent adenovirus platform for in situ production of RNA aptamers targeting 4-1BB, showing antitumor activity comparable to a 4-1BBL-expressing adenovirus.
bioRxiv · Mar 3, 2026 · PreprintCancer Biology