Author

Ignacio Melero

Churchill HospitalORCID 0000-0002-1360-348XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. CarteriD· 1 shared Alistair EastoniD· 1 shared Ana Patiño‐GarcíaiD· 1 shared Andréa E. TijhuisiD· 1 shared Antonio Tallón· 1 shared Benjamin IzariD· 1 shared Bruno BeernaertiD· 1 shared Candelaria Gomez‐ManzanoiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. CarterORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS-chemokine-myeloid axis

Bruno Beernaert, Rose L. Jady‐Clark, Parin Shah, Erik Ramon‐Gil, Nora M. Lawson, Zack D Brodtman, Somnath Tagore, Frederik Stihler, A. Carter, Shannique Clarke, Tong Liu, Winston M. Zhu, Juliet E. Martin, Erkin Erdal, Alistair Easton, , Eileen E. Parkes

This study shows that chromosomal instability in esophageal adenocarcinoma drives an inflammatory tumor microenvironment through a cGAS-chemokine-myeloid axis, with CXCL8 as a key mediator.

Science Advances · Mar 11, 2026Peer-reviewedCancer Biology

Replication competent adenoviral platform for in situ production of immunotherapeutic RNA aptamers targeting 4 1BB

Antonio Tallón, Virginia Laspidea, Iker Ausejo‐Mauleon, Daniel de la Nava, Sara Labiano, Marisol González-Huarriz, Marta Zalacaín, Ana Patiño‐García, Helena Villanueva, Juan Fueyo-Margareto, Candelaria Gomez‐Manzano, Ignacio Melero, Fernando Pastor, Marta M. Alonso, Marc Garcia Moure

This paper develops a replication-competent adenovirus platform for in situ production of RNA aptamers targeting 4-1BB, showing antitumor activity comparable to a 4-1BBL-expressing adenovirus.

bioRxiv · Mar 3, 2026 · PreprintCancer Biology

Hiltonol and Protamine-RNA stimulation induce an immune-activating transcriptome profile in cDC1s

Georgina Flórez‐Grau, Till S. M. Mathan, Mihaela Mihaylova, Tom G.M. van Oorschot, Gerty Schreibelt, David Sancho, Ignacio Melero, Carl Gustav Figdor, I. Jolanda M. de Vries, Johannes C. Textor

The paper evaluates how Hiltonol and protamine-RNA stimulate human cDC1s, showing similar transcriptome changes related to immune activation without synergistic effects.

bioRxiv · Oct 13, 2025 · PreprintImmunology