Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis
Daniel Halperin, Chrystian Junqueira Alves, Marcelle Rodrigues Lemos, Soumyadeb Dey, Haochen Tao, Sangjo Kang, Xianting Li, Zhenyu Yue, Jiaxi Li, Rodrigo Alves Dias, Gustavo de Oliveira Rosa, José Paulo Rodrigues Furtado de Mendonça, Molly S. Estill, Yonatan Perez, Susana Isabel Ramos, , Hongyan Zou
This study identifies cortical tension as a mechanical barrier that prevents premature neuronal differentiation during neurogenesis, showing that reducing it accelerates neuronal lineage commitment and differentiation.
bioRxiv · Sep 19, 2025 · PreprintNeuroscience