N-cadherin in osteolineage cells restrains breast cancer cell growth via inhibition of a PI3K-dependent, Tgf-β1-driven feed-forward loop
Toshifumi Sugatani, Kate Yeo, Marco A Campioli, Hillary Fujimoto, Roberto Civitelli
This study shows that N-cadherin in osteolineage cells inhibits breast cancer growth by blocking a Tgf-β1-driven feed-forward loop involving PI3K-Akt-β-catenin signaling.
bioRxiv · Oct 22, 2025 · PreprintCancer Biology