Roberto Civitelli

This study shows that N-cadherin in osteolineage cells inhibits breast cancer growth by blocking a Tgf-β1-driven feed-forward loop involving PI3K-Akt-β-catenin signaling.

The paper identifies six genes with causal roles in aging by analyzing gene expression across species and testing their effects on lifespan in C. elegans.

This study finds that inflammation in bone of T2D and obesity patients is linked to reduced Wnt signaling and lower bone strength.

This study shows that Cx43 in mesenchymal lineage cells reduces body adiposity and improves metabolic health in mice on a high-fat diet.

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.