Inhibitor fluorination pattern tunes chemically induced protein dimerization
Eric Schwegler, Jean-Martin Harder, Marco D. Preuss, Charlotte Guhl, Shuai‐Bing Zhang, Annika Wagner, Nicole Bader, Pierre Stallforth, Markus Lakemeyer, Hermann Schindelin, Till Opatz, Ute A. Hellmich
This study shows that fluorination of inhibitors can tune protein dimerization affinity by altering enzyme-inhibitor interactions and dynamics.
bioRxiv · Jul 23, 2025 · PreprintBiophysics