Author

Charlotte Guhl

Friedrich Schiller University JenaORCID 0000-0002-5301-0064Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Ute A. HellmichiD· 2 shared Annika WagneriD· 1 shared Aron KolleriD· 1 shared Eric SchwegleriD· 1 shared Eva-Maria Eckl· 1 shared Hermann SchindeliniD· 1 shared Jean-Martin HarderiD· 1 shared Laura Hoffmann· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Ute A. HellmichORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Inhibitor fluorination pattern tunes chemically induced protein dimerization

Eric Schwegler, Jean-Martin Harder, Marco D. Preuss, Charlotte Guhl, Shuai‐Bing Zhang, Annika Wagner, Nicole Bader, Pierre Stallforth, Markus Lakemeyer, Hermann Schindelin, Till Opatz, Ute A. Hellmich

This study shows that fluorination of inhibitors can tune protein dimerization affinity by altering enzyme-inhibitor interactions and dynamics.

bioRxiv · Jul 23, 2025 · PreprintBiophysics

AMPylation regulates PLD3 processing.

Laura Hoffmann, Eva-Maria Eckl, Marleen Bérouti, Mette Pries, Aron Koller, Charlotte Guhl, Ute A. Hellmich, Veit Hornung, Wei Xiang, Lucas T. Jae, Pavel Kielkowski

This study identifies AMPylation as a key regulator of PLD3 processing and catalytic activity, showing its role in neurodegenerative diseases like Parkinson's.

bioRxiv · Jan 9, 2025 · PreprintBiochemistry