GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release
Carlos G. Ardanaz, Aida de la Cruz, Marcos Elizalde-Horcada, Elena Puerta, María Javier Ramírez, Jorge Emilio Ortega, Ainhoa Urbiola, Cristina Ederra, Mikel Ariz, Carlos Ortíz-de-Solórzano, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Gérard Karsenty, Jens C. Brüning, Maite Solas
This study shows that removing GLUT1 in astrocytes improves brain and peripheral glucose metabolism without affecting cognition, due to increased insulin-stimulated ATP release.
bioRxiv · Oct 6, 2022 · PreprintNeuroscience