Jorge Emilio Ortega

This study develops a mouse model of locus coeruleus alpha-synuclein overexpression to investigate early Parkinson's disease features, finding functional and neurochemical disruptions without neuronal loss.

This study compares different CUMS protocols in mice, finding that increased stress intensity, frequency, and duration lead to more pronounced depressive and anxiety-like behaviors, adrenal hypertrophy, and reduced body weight gain.

This study shows that removing GLUT1 in astrocytes improves brain and peripheral glucose metabolism without affecting cognition, due to increased insulin-stimulated ATP release.

The paper shows that peripheral CB1R blockade enhances non-emotional memory through an adrenergic-dependent mechanism in mice.