Gérard Karsenty

Bone regulates locomotion by sustaining motoneuronal mitochondrial function

This study shows that bone-derived hormone osteocalcin regulates locomotion by maintaining mitochondrial function in spinal motoneurons, and that this effect can be reversed in aged mice.

A skeletal muscle-sympathetic nerve-intestine network underlies muscle inflammation and atrophy induced by immobilization

This study identifies a muscle-sympathetic nerve-intestine network that drives inflammation and atrophy in immobilized muscles, showing that intestinal inflammation contributes to muscle damage.

GLUT1 ablation in astrocytes paradoxically improves central and peripheral glucose metabolism via enhanced insulin-stimulated ATP release

This study shows that removing GLUT1 in astrocytes improves brain and peripheral glucose metabolism without affecting cognition, due to increased insulin-stimulated ATP release.