Targeting xCT-Mediated Glutamate Release Normalizes Tumor Angiogenesis In The Brain
Zheng Fan, Thomas Broggini, Eduard Yakubov, Tina Sehm, Sebastian Schürmann, Eric P. Meyer, Nevenka Dudvarski Stankovic, Mirko HH. Schmidt, Marco Stampanoni, Marcus A. Czabanka, Robert Nitsch, Michael Buchfelder, Oliver Friedrich, Ilker Y. Eyupoglu, Nicolai E. Savaskan
This study shows that targeting xCT reduces tumor angiogenesis in brain tumors by affecting endothelial cells via glutamate and NMDAR.
bioRxiv · May 18, 2017 · PreprintCell Biology