Author

Marek Havelka

Masaryk University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein sequence· 1

Frequent Co-Authors

Andrea KnightiD· 4 shared Martin PiskáčekiD· 4 shared Kristína JendruchováiD· 2 shared Martina ŘezáčováiD· 2 shared Alena HofrováiD· 1 shared Liam P. KeeganiD· 1 shared Norbert GašparikiD· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 18 mutual co-author links

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4 shared papersMolecular Biology

Andrea KnightORCID

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Author profile →

4 papers

Recent·Most cited

The 9aaTAD activation domains in the four Yamanaka Oct4, Sox2, Myc, and Klf4 transcription factors essential during the stem cell development

Martin Piskáček, Kristína Jendruchová, Martina Řezáčová, Marek Havelka, Norbert Gašparik, Alena Hofrová, Andrea Knight

The paper identifies 9aaTAD activation domains in Yamanaka factors as key interfaces for transcriptional activation and reprogramming.

bioRxiv · Dec 15, 2019 · PreprintGenetics

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs

Martin Piskáček, Marek Havelka, Kristína Jendruchová, Andrea Knight, Liam P. Keegan

The paper investigates the evolution of the 9aaTAD domain in Sp2 proteins, showing that valine accumulation inactivates the domain and that loss of valines allowed functional recovery in paralogs.

Cellular and Molecular Life Sciences · Aug 2, 2019Peer-reviewedMolecular Biology

How to overcome the ATRA resistance with the 9aaTAD activation domains in retinoic acid receptors

Martin Piskacek, Marek Havelka, Andrea Knight

This study shows that 9aaTAD domains from nuclear hormone receptors can activate transcription independently of NCoA adaptors and suggests using these domains to overcome ATRA resistance in PML-RARa leukemia.

bioRxiv · Apr 10, 2018 · PreprintCancer Biology

Gal4 activation domain 9aaTAD could be inactivated by adjacent mini-inhibitory domain and reactivated by distal re-activation domain

Martin Piskáček, Marek Havelka, Martina Řezáčová, Andrea Knight

The paper clarifies that the 9aaTAD activation domain in Gal4 can be inhibited by an adjacent 10aa inhibitory domain and reactivated by a distal 13aa re-activation domain, resolving previous misconceptions.

bioRxiv · Feb 22, 2017 · PreprintMolecular Biology