Yeast Rai1p and the RAC complex (Ssz1p/Zuo1p) modulate uORF-mediated GCN4 translational control under stress conditions.
Kristína Jendruchová, Adriana Šubrtova, Leoš Shivaya Valášek
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Czech Academy of Sciences, Institute of MicrobiologyORCID 0009-0006-2635-6867Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Kristína Jendruchová, Adriana Šubrtova, Leoš Shivaya Valášek
Anna M. Smirnova, Vladislava Hronová, Mahabub Pasha Mohammad…·Leoš Shivaya Valášek
The paper identifies a stem-loop and modified adenines in the uORF2/ATF4 overlap that regulate ATF4 translation under stress, revealing a more complex mechanism than previously thought.
Kristína Jendruchová, Swati Gaikwad, Kristýna Poncová…·Alan G. Hinnebusch
The paper investigates how yeast Tma proteins affect translation reinitiation at upstream open reading frames (uORFs) and finds that their impact varies based on uORF characteristics and penultimate codons, not solely on bulk recycling dependence.
Martin Piskáček, Kristína Jendruchová, Martina Řezáčová…·Andrea Knight
The paper identifies 9aaTAD activation domains in Yamanaka factors as key interfaces for transcriptional activation and reprogramming.
Martin Piskáček, Marek Havelka, Kristína Jendruchová…·Liam P. Keegan
The paper investigates the evolution of the 9aaTAD domain in Sp2 proteins, showing that valine accumulation inactivates the domain and that loss of valines allowed functional recovery in paralogs.