Author
Masaryk UniversityORCID 0000-0001-7291-7975Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Andrea Knight, Josef Houser, Tomáš Otaševič…·Martin Piskáček
The paper identifies a conserved 9aaTAD region in c-Myc and N-Myc that binds the KIX domain with high affinity, suggesting a potential druggable target for MYC-driven tumors.
Martin Piskáček, Kristína Jendruchová, Martina Řezáčová…·Andrea Knight
The paper identifies 9aaTAD activation domains in Yamanaka factors as key interfaces for transcriptional activation and reprogramming.
Martin Piskáček, Marek Havelka, Kristína Jendruchová…·Liam P. Keegan
The paper investigates the evolution of the 9aaTAD domain in Sp2 proteins, showing that valine accumulation inactivates the domain and that loss of valines allowed functional recovery in paralogs.
Martin Piskacek, Marek Havelka, Andrea Knight
This study shows that 9aaTAD domains from nuclear hormone receptors can activate transcription independently of NCoA adaptors and suggests using these domains to overcome ATRA resistance in PML-RARa leukemia.
Martin Piskáček, Marek Havelka, Martina Řezáčová, Andrea Knight
The paper clarifies that the 9aaTAD activation domain in Gal4 can be inhibited by an adjacent 10aa inhibitory domain and reactivated by a distal 13aa re-activation domain, resolving previous misconceptions.