Robust T cell activation requires an eIF3-driven burst in T cell receptor translation
Dasmanthie De Silva, Lucas Ferguson, Grant H. Chin, Benjamin E. Smith, Ryan Apathy, Theodore L. Roth, Franziska Blaeschke, Marek Kudla, Alexander Marson, Nicholas T. Ingolia, Jamie H. D. Cate
This study identifies eIF3's role in regulating TCR translation via 3-UTR binding, enhancing CAR-T cell efficacy in vitro.
eLife · Dec 31, 2021Peer-reviewedMolecular Biology