Author

Dasmanthie De Silva

Gladstone InstitutesORCID 0000-0001-6824-0850Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jamie H. D. CateiD· 3 shared Alexander MarsoniD· 2 shared Benjamin E. SmithiD· 2 shared Grant H. ChiniD· 2 shared Lucas FergusoniD· 2 shared Marek Kudla· 2 shared Nicholas T. IngoliaiD· 2 shared Theodore L. RothiD· 2 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMolecular Biology

Jamie H. D. CateORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJun 19, 2026

eIF3 interactions with miRNAs involved in translational control of early T cell activation

Pooja Mukherjee, Jiwon Shin, Cynthia Hermosillo…·Jamie H. D. Cate

The paper investigates eIF3 interactions with miRNAs during early T cell activation, finding that eIF3 binds miR-17~92 cluster miRNAs and that their disruption affects T cell activation markers.

DOI 10.64898/2026.06.17.732961

humanbulk RNA-seq

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Molecular BiologyeLifePeer-reviewedDec 31, 2021

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

Dasmanthie De Silva, Lucas Ferguson, Grant H. Chin…·Jamie H. D. Cate

This study identifies eIF3's role in regulating TCR translation via 3-UTR binding, enhancing CAR-T cell efficacy in vitro.

34 citations

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintDec 20, 2019

A burst in T cell receptor translation mediated by eIF3 interactions with T cell receptor mRNAs

Dasmanthie De Silva, Lucas Ferguson, Benjamin E. Smith…·Jamie H. D. Cate

The paper identifies eIF3's role in enhancing TCR translation during T cell activation through interactions with 3-UTRs of TCR mRNAs.

1 citation

humanmetagenomics

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