Synthesis and Biological Evaluation of Nipecotic Acid Derivatives with Terminally Double-Substituted Allenic Spacers as mGAT4 Inhibitors
Maren Jung, Kinga Sałat, Georg C. Höfner, Jörg Pabel, Elżbieta Wyska, Marek Sierżęga, Anna Furgała, Christoph G. W. Gertzen, Holger Gohlke, Klaus T. Wanner
This paper synthesizes and evaluates nipecotic acid derivatives with allenic spacers as mGAT4 inhibitors, identifying a potent compound with anticonvulsant and anxiolytic effects in mice.
Journal of Medicinal Chemistry · Sep 18, 2025Peer-reviewedPharmacology & Toxicology