Christoph G. W. Gertzen

ATPLyzer An advanced ratiometric multi-colour biosensor for long-term monitoring of ATP dynamics

The paper introduces ATPLyzer, a ratiometric biosensor for monitoring ATP dynamics, showing its utility in E. coli and demonstrating growth-phase and carbon-supply-dependent ATP changes.

A novel biosensor for ferrous iron developed via CoBiSe:A computational method for rapid biosensor design

The paper introduces CoBiSe, a computational method for biosensor design, and demonstrates its application in creating IronSenseR, a biosensor for ferrous iron with high specificity and sensitivity.

Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells

This paper introduces a C-terminal HSP90 dimerization inhibitor, VWK147, which induces cell death in cisplatin-resistant cancer cells and synergizes with mTOR inhibition to enhance therapeutic efficacy.

Synthesis and Biological Evaluation of Nipecotic Acid Derivatives with Terminally Double-Substituted Allenic Spacers as mGAT4 Inhibitors

This paper synthesizes and evaluates nipecotic acid derivatives with allenic spacers as mGAT4 inhibitors, identifying a potent compound with anticonvulsant and anxiolytic effects in mice.

Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents

This study synthesizes and evaluates new MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after nerve agent intoxication, identifying more potent compounds than MB327.