Notch-Jagged signaling complex defined by an interaction mosaic
Matthieu R. Zeronian, Oleg V. Klykov, Júlia Portell i de Montserrat, Maria J. Konijnenberg, Anamika Gaur, Richard A. Scheltema, Bert J. C. Janssen
The paper identifies five interaction regions between Notch1 and Jagged1 using XL-MS and SAXS, revealing a backfolded architecture that redefines the activation mechanism of Notch-Jagged signaling.
Proceedings of the National Academy of Sciences · Jul 23, 2021Peer-reviewedMolecular Biology