Author

Oleg V. Klykov

The University of Texas at San Antonio Health Science CenterORCID 0000-0003-4401-9400Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:mouse· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

Alex de MarcoiD· 1 shared Anamika GauriD· 1 shared Andreas HoengeriD· 1 shared Ash WeieriD· 1 shared Bert J. C. JansseniD· 1 shared Edward T. EngiD· 1 shared Elliot T Morgan· 1 shared Fabio A Vigil· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Alex de MarcoORCID

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2 papers

Recent·Most cited

BiophysicsCell Reports MethodsPeer-reviewedSep 1, 2026

Cryoprotectants-assisted plunge freezing of thick brain tissue specimens for targeted physiologically relevant cryo-imaging in situ

Ash Weier, Fei Gao, Elliot T Morgan…·Oleg V. Klykov

This paper develops a cryoprotectant-assisted plunge freezing method for preserving thick mouse brain tissue for cryo-imaging, enabling high-resolution visualization of cellular structures and validating their physiological relevance.

1 citation

mousecryo-EM

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Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedJul 23, 2021

Notch-Jagged signaling complex defined by an interaction mosaic

Matthieu R. Zeronian, Oleg V. Klykov, Júlia Portell i de Montserrat…·Bert J. C. Janssen

The paper identifies five interaction regions between Notch1 and Jagged1 using XL-MS and SAXS, revealing a backfolded architecture that redefines the activation mechanism of Notch-Jagged signaling.

26 citations

experimental assay

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