Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewed
Notch-Jagged signaling complex defined by an interaction mosaic
Matthieu R. Zeronian, Oleg V. Klykov, Júlia Portell i de Montserrat…·Bert J. C. Janssen
The paper identifies five interaction regions between Notch1 and Jagged1 using XL-MS and SAXS, revealing a backfolded architecture that redefines the activation mechanism of Notch-Jagged signaling.
26 citations