Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system
Melany Jackson, A Fidanza, A. Helen Taylor, Рыбцов Станислав Александрович, Richard A Axton, Maria Kydonaki, Stephen E. Meek, Tom Burdon, Alexander Medvinsky, Lesley M. Forrester
This study shows that Aplnr signaling is essential for generating hematopoietic stem cell precursors during development but must be downregulated for their maintenance.
Stem Cell Reports · Mar 7, 2021Peer-reviewedDevelopmental Biology