Lesley M. Forrester

LIMK Inhibition and Metformin Block Mitochondrial Transfer Overcoming Macrophage Driven Therapy Resistance in Acute Myeloid Leukaemia

This study identifies mitochondrial transfer from M2-like macrophages to AML cells as a mechanism of chemoresistance, showing that LIMK inhibition and metformin block this transfer and restore chemosensitivity.

Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms

This study generates cardiac resident-like macrophages and cardiomyocytes from iPSCs to investigate their interactions in 2D and 3D settings, showing improved cardiomyocyte maturation and function when co-cultured.

Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2.

The paper identifies IGFBP2 as a key factor secreted by arterial cells that enhances hematopoietic progenitor development in vitro.

Endothelial-specific Gata3 expression is required for haematopoietic stem cell generation

This study shows that endothelial-specific Gata3 expression is required for the maturation of haemogenic endothelial cells into haematopoietic stem cells during the endothelial-to-haematopoietic transition.

Modulation of Aplnr signaling is required during the development and maintenance of the hematopoietic system

This study shows that Aplnr signaling is essential for generating hematopoietic stem cell precursors during development but must be downregulated for their maintenance.

Single cell transcriptome analysis reveals markers of naive and lineage-primed hematopoietic progenitors derived from human pluripotent stem cells.

The paper identifies markers of naive and lineage-primed hematopoietic progenitors from hPSCs using single-cell RNA sequencing and functional assays.