Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial superinfection susceptibility
Kehinde Adebayo Babatunde, Mtakai Ngara, Paola Martinez-Murillo, Bibin Yesodha Subramanian, Alex R. Hopke, Simone Lucchesi, Maria Novedrati, Giorgio Montesi, Francesco Santoro, Michael Hagemann-Jensen, Rickard Sandberg, Luis Filgueira, Michael Walch, Daniel Irimia, Pierre‐Yves Mantel
This study shows that Plasmodium falciparum uses extracellular vesicles to deliver miR-451a to neutrophils, impairing their antimicrobial function and increasing susceptibility to bacterial superinfections.
bioRxiv · Jun 2, 2025 · PreprintImmunology