Rickard Sandberg

This study compares lipid-conjugated ASO delivery in mice, showing differential tissue and CNS targeting based on lipid type and administration route.

RNA BaseCode is a synthetic long-read RNA sequencing method that achieves short-read accuracy and improves full-length transcript reconstruction compared to existing long-read methods.

This study shows that Plasmodium falciparum uses extracellular vesicles to deliver miR-451a to neutrophils, impairing their antimicrobial function and increasing susceptibility to bacterial superinfections.

The paper introduces a method to control cell fates by modulating multiple genes using CRISPR tools and machine learning, demonstrating its effectiveness in stem cell differentiation.

The paper creates a cell atlas of the adult mouse oesophagus, revealing regionalized cell and gene signatures that govern epithelial homeostasis and disease susceptibility.

The paper identifies a striosomal ACB projection to the Esr1+ LHA-LHb pathway that drives compulsive seeking behaviors through aversive signaling.

This paper introduces a synthetic thermostable RNase inhibitor that improves single-cell RNA-seq library quality, reproducibility, and workflow flexibility compared to protein-based inhibitors.

The paper identifies heritable transcriptional diversity within cell types by studying clonal human lymphocytes and mouse brain cells, showing clone-specific chromatin accessibility leads to distinct gene expression.

The paper investigates how chromatin state influences transcriptional burst kinetics and RNA Polymerase II pausing during Drosophila embryonic patterning.

The paper introduces molecular spikes as a gold standard to evaluate RNA counting accuracy in single-cell RNA-sequencing methods.

STORM-seq improves single-cell RNA sequencing by enhancing detection of non-coding transcripts and transcript-level complexity, revealing new cell states in human fallopian tube epithelium.

This study investigates the transcriptional dynamics and functions of long non-coding RNAs using single-cell RNA-seq, revealing distinct burst kinetics and cell-state specific roles.

anonymizeBAM removes donor-related genetic information from sequence data, enabling secure open data sharing in genomics.

The paper introduces a scalable, cost-effective single-cell RNA sequencing method that generates a detailed human blood cell atlas with high sensitivity and throughput.

The paper simulates interactions between risk factors to assess additive and multiplicative models, finding that synergistic factors lead to multiplicative risks and thresholds create intermediate effects.

This study shows transcriptional bursts explain autosomal monoallelic expression and influence allelic imbalance in scRNA-seq data.

PhylEx reconstructs clonal structure by integrating bulk DNA-seq and scRNA-seq data, outperforming existing methods in clonal-tree reconstruction and mutation clustering.

The paper combines morpho-electric and transcriptomic data from mouse motor cortex neurons to show that transcriptomic types within families form continuous morpho-electric landscapes rather than discrete entities.

This study uses LCM-seq to analyze transcriptional changes in SMA, identifying cell-type specific adaptations that explain resistance in ocular motor neurons.

This paper introduces Smart-seq3, a single-cell RNA sequencing method that enables allele- and isoform-resolution RNA counting, showing improved sensitivity and isoform regulation detection in mouse and human samples.

This study benchmarks 13 scRNA-seq protocols to evaluate their effectiveness in characterizing cell types and states for cell atlas projects.

The paper characterizes cell types and circuit organization within neocortical radial clones using single-cell RNA-sequencing and electrophysiological recordings, finding that clones contain diverse cell types and exhibit specific connectivity patterns.

The paper analyzes allele-specific scRNA-seq data to show that X-chromosome upregulation in mouse cells occurs through increased transcriptional burst frequency.

The paper identifies distinct cell types and circuit organization in layer 4 of primary sensory areas in adult mouse neocortex, challenging the canonical microcircuit model.

NASC-seq monitors newly synthesized RNA in single cells, revealing dynamic gene expression during T-cell activation.

The paper reanalyzes previous findings on X-linked gene expression in human preimplantation embryos and challenges a recent reanalysis that disputes biallelic expression dampening.

This paper presents a computational method to correct cross-contamination in sequencing data, reducing false positives and spurious clustering by 80-90%.