IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site
Paula G. Socuéllamos, Carmen Viedma-Barba, Ángela de Benito-Bueno, M. Ángeles Bonache, Maria Ropero, Sara Diez, Pablo Elizalde, Irene Marín-Olivero, Maria Redondo, José R. Naranjo, Juan Antonio Gonzalez‐Vera, Ángel Orte, Ángel Pérez-Lara, Mercedes Martín‐Martinez, Carmen Valenzuela, Marta Gutiérrez‐Rodríguez
This study identifies IQM-22110 as a selective KV4.3/KChIP3 modulator, showing it binds specifically to KV4.3/KChIP3 and not KV4.3/KChIP2 or KV4.3 alone.
bioRxiv · May 29, 2025 · PreprintPharmacology & Toxicology