Author

Ángela de Benito-Bueno

Instituto de Investigaciones Biomédicas Sols-MorrealeORCID 0000-0002-2499-3145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:electrophysiology· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Carmen ValenzuelaiD· 3 shared Paula G. SocuéllamosiD· 3 shared Marta Gutiérrez‐RodrígueziD· 2 shared Alberto Forteza GiliD· 1 shared Alicia de la CruziD· 1 shared Álvaro MacíasiD· 1 shared Ángel OrteiD· 1 shared Ángel Pérez-LaraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersPharmacology & Toxicology

Carmen ValenzuelaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel insights into IKur modulation by Lgi3-4: Implications in atrial fibrillation

Paula G. Socuéllamos, Álvaro Macías, Ángela de Benito-Bueno, Francisco Miguel Cruz, María Redondo-Moya, María José Coronado, Elvira Ramil, Silvia Rosado, Elsa Carolina Rios-Rosado, María Valencia-Avezuela, Laura de Andrés-Delgado, José Antonio Blázquez, Alberto Forteza Gil, Marta Gutiérrez‐Rodríguez, José Jalife, Carmen Valenzuela

This study shows Lgi3-4 modulate IKur by interfering with KV1.5-KVβ interactions, contributing to atrial fibrillation pathophysiology.

Cardiovascular Research · Mar 19, 2026Peer-reviewedPhysiology

IQM-22110 as a selective KV4.3/KChIP3 modulator. Molecular determinants of the KChIP3 binding site

Paula G. Socuéllamos, Carmen Viedma-Barba, Ángela de Benito-Bueno, M. Ángeles Bonache, Maria Ropero, Sara Diez, Pablo Elizalde, Irene Marín-Olivero, Maria Redondo, José R. Naranjo, Juan Antonio Gonzalez‐Vera, Ángel Orte, Ángel Pérez-Lara, Mercedes Martín‐Martinez, Carmen Valenzuela, Marta Gutiérrez‐Rodríguez

This study identifies IQM-22110 as a selective KV4.3/KChIP3 modulator, showing it binds specifically to KV4.3/KChIP3 and not KV4.3/KChIP2 or KV4.3 alone.

bioRxiv · May 29, 2025 · PreprintPharmacology & Toxicology

RvD1 and LXA4 inhibitory effects on cardiac voltage-gated potassium channels

Alicia de la Cruz, Carlotta Ronchi, Chiara Bartolucci, Paula G. Socuéllamos, Ángela de Benito-Bueno, Stefano Severi, Antonio Zaza, Carmen Valenzuela

This study investigates the effects of RvD1 and LXA4 on cardiac voltage-gated potassium channels in vitro and in silico, finding RvD1 more potent in inhibiting IKs and IKr.

Biomedicine & Pharmacotherapy · Apr 22, 2025Peer-reviewedPharmacology & Toxicology