Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals
Pravrutha Raman, Hana Khan, Janet M. Young, Rebecca Ferreira Alves, Maria Toro Moreno, Alice L. Li, Alice H. Berger, Toshio Tsukiyama, Harmit Singh Malik
EZHIP, a PRC2 inhibitor, arose on the placental mammal X chromosome, evolves under positive selection in primates, and duplicated, including a testis-expressed primate paralog, EZHIP2, whose gorilla copy inhibits H3K27me3.
bioRxiv · Oct 17, 2026 · PreprintEvolutionary Biology✦ In-depth digest