Toshio Tsukiyama

EZHIP, a PRC2 inhibitor, arose on the placental mammal X chromosome, evolves under positive selection in primates, and duplicated, including a testis-expressed primate paralog, EZHIP2, whose gorilla copy inhibits H3K27me3.

The paper shows that chromatin architecture limits replication origin licensing capacity in budding yeast by restricting helicase loading through Isw2-dependent nucleosome repositioning.

This study identifies a unique condensed 3D chromatin structure of rDNA in quiescent yeast cells and shows that Sir2 is essential for maintaining this structure and proper quiescence transitions.

This study shows that acidic media pH improves quiescence entry efficiency in Saccharomyces cerevisiae without affecting thermotolerance.

The paper shows that chromatin fiber folding in quiescent yeast represses transcription and loop extrusion, with H4 tail modifications affecting fiber structure and function.

This study shows that RSC primes quiescent chromatin for rapid transcription upon cell cycle re-entry by pre-binding target genes and facilitating Pol II loading and transcription.

This study identifies condensin-mediated chromatin condensation as a mechanism repressing transcription during quiescence in yeast and human cells.

This paper shows that Isw2 and Ino80 chromatin remodeling factors regulate nucleosome occupancy, positioning, and replication at the yeast rDNA locus.

This study shows that the SWI/SNF complex activates quiescence-specific genes by facilitating Gis1 localization and histone hypoacetylation, counteracting Rpd3-mediated repression during quiescence entry.