Janet M. Young

EZHIP, a PRC2 inhibitor, arose on the placental mammal X chromosome, evolves under positive selection in primates, and duplicated, including a testis-expressed primate paralog, EZHIP2, whose gorilla copy inhibits H3K27me3.

This study identifies ACTL8 as a nuclear actin-related protein that modulates transcription through interaction with KDM5B, affecting migration pathways in cancer cells.

The paper analyzes homing endonuclease genes, identifies their activity levels, and reconstructs ancestral forms showing improved function and structural insights.

The paper identifies previously unknown Scm3/HJURP orthologs in metazoans using remote homology, structural modeling, and functional genetics, revealing their conserved role in centromere function despite sequence divergence.

The paper investigates the role of the Drosophila maternal-effect gene ao in histone gene repression and finds that ao does not repress histone gene expression.

The paper investigates the rapid evolution of self/non-self recognition genes in Dictyostelium by analyzing genome sequences and identifying a hypermutable hotspot in the tgrBC locus.

The paper maps YFV interactomes in human and mosquito cells, identifies RBBP6 as a restriction factor, and reveals divergent host interaction strategies among flaviviruses.

This study identifies how RNF213 recognizes diverse pathogens through enzymatic amplification of cooperative recruitment.

The paper analyzes the evolutionary trajectories of domesticated metaviral capsid genes in mammals, revealing diverse outcomes and structural features of these genes.

The paper shows that evolutionarily dynamic ZAD-ZNF genes in Drosophila are more likely to be essential, with Nicknack being necessary for larval development despite its rapid evolution.

Affinity-purification mass spectrometry of 26 SARS-CoV-2 proteins in HEK293T cells yields 332 high-confidence host interactions and 67 druggable human proteins with known compounds.