Pravrutha Raman

EZHIP, a PRC2 inhibitor, arose on the placental mammal X chromosome, evolves under positive selection in primates, and duplicated, including a testis-expressed primate paralog, EZHIP2, whose gorilla copy inhibits H3K27me3.

The paper shows that RNA interference selectivity in C. elegans arises from gene-specific RNA metabolism and restricted amplification, not specialized pathways.

The paper shows that heritable RNA silencing in C. elegans can occur through multiple distinct mechanisms, each detectable by unique mRNA fragment signatures.

The paper shows that gene-specific homeostasis in C. elegans enables recovery from transgenerational RNA silencing, with silencing persisting for over 250 generations under certain conditions.

The paper shows that long dsRNA binding by RDE-4 is required for systemic RNAi in C. elegans, contradicting previous findings using repetitive transgenes.