Premature cleavage and polyadenylation in the minor intron of PTEN modulate its expression and generates a functional long non-coding RNA in breast cancer
Mariam Elesnawy, Rim Elghandour, Hana Hasna, Aisha D. Fakhroo, Boshra AlSulaiti, Ihab Younis
The paper identifies a novel mechanism where premature cleavage and polyadenylation of the minor intron in PTEN generates a functional lncRNA, PINC, which modulates cellular proliferation in breast cancer.
iScience · Apr 14, 2026Peer-reviewedCancer Biology