Genotoxic formaldehyde and lipid aldehydes are sources of DNA damage in keratinocytes
Nicolas J. Blobel, Yibing Yao, Marian Okondo, Agata Smogorzewska
This study identifies ADH5 and ALDH3-family enzymes as critical for detoxifying endogenous aldehydes in FA-deficient keratinocytes, preventing DNA damage and carcinogenesis.
bioRxiv · Nov 13, 2025 · PreprintCell Biology