Depopulation of α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson disease model
Michał Węgrzynowicz, Dana Bar-On, Laura Calò, Oleg V. Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov, Andrei Leonov, Armin Giese, Jeffrey W. Dalley, Christian Griesinger, Uri Ashery, Maria Grazia Spillantini
This study develops a new Parkinson's disease mouse model showing that reducing α-synuclein aggregates rescues dopamine neuron dysfunction and death.
Acta Neuropathologica · May 31, 2019Peer-reviewedNeuroscience