Jeffrey W. Dalley

Modulatory effects of α7-nicotinic cholinergic receptors on perceptual sensitivity in a visual signal detection task

This study investigates how α7-nicotinic cholinergic receptors affect perceptual sensitivity in a visual signal detection task, finding dose-dependent improvements with antagonists and impairments with agonists and modulators.

Enhanced visual perceptual learning by positive allosteric modulation of α5 subunit-containing GABA-A receptors: putative association with the prelimbic cortex

This study shows that GABRA5 expression in the prelimbic cortex correlates with visual perceptual learning speed and that a GABRA5 modulator improves learning in poor performers.

Detrimental effects of atomoxetine on visual signal detection in rats: Comparison with ADHD psychomotor stimulant drugs

This study compares the effects of atomoxetine and ADHD stimulants on visual attention in rats, finding atomoxetine impairs attention while stimulants have variable effects.

Neurobehavioural correlates of changing one's mind in ADHD and OCD

This study examines neurobehavioural differences in ADHD and OCD patients during a cognitive flexibility task, finding distinct patterns of response switching and brain activity.

Maternal separation recalibrates prefrontal mitochondrial function and protects against stress-induced negative cognitive bias

This study shows that early maternal separation in rats increases prefrontal mitochondrial function and protects against stress-induced negative cognitive bias in adulthood.

Impacts and interactions of stress, noradrenaline and serotonin signalling on probabilistic reversal learning

This study investigates how early life stress affects probabilistic reversal learning in rats and examines the role of noradrenergic and serotonergic systems in modulating this effect.

Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Non-Occurrence of Visual Signals in Perceptual Decision-Making

This study shows that dopamine fluctuations in the nucleus accumbens reflect reward prediction errors incorporating confidence and uncertainty during visual decision-making in rats.

The brain cortical similarity network: Development and sensitivity to early life stress in a rat model

The paper uses MRI similarity network analysis to study how early life stress affects cortical network development in rats, finding altered inter-areal similarity in key brain regions.

Mesencephalic projections to the nucleus accumbens shell modulate value updating during probabilistic reversal learning

This study shows that optogenetic stimulation of VTA to NAcbS projections impairs reversal learning and increases exploitation bias in rats during probabilistic reversal learning.

Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum

The paper develops a computational model of dopamine dynamics in the striatum, revealing regional differences in dopamine transporter activity and receptor response kinetics.

Computational modeling of reinforcement learning and functional neuroimaging of probabilistic reversal dissociates compulsive behaviors in Gambling and Cocaine Use Disorders

The paper uses reinforcement learning models and fMRI to analyze cognitive flexibility differences in Gambling Disorder and Cocaine Use Disorder, finding distinct neural and behavioral patterns.

Neurobehavioral precursors of compulsive cocaine-seeking in dual fronto-striatal circuits

The paper identifies neurobehavioral markers in rats that predict future compulsive cocaine seeking behavior through pre-existing functional and structural brain changes.

CSPα reduces aggregates and rescues striatal dopamine release in αsynuclein transgenic mice

This study shows that CSP reduces synuclein aggregates and restores dopamine release in a Parkinson's disease mouse model.

Depopulation of α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson disease model

This study develops a new Parkinson's disease mouse model showing that reducing α-synuclein aggregates rescues dopamine neuron dysfunction and death.

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

This study shows mTORC1 in AGRP neurons integrates food-related cues to control iBAT thermogenesis in mice, linking energy availability to adaptive energy expenditure.