Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells
Isabelle Hébert-Milette, Chloé Lévesque, Jean Paquette…·John David Rioux
This study shows that C1ORF106 and its IBD variant regulate intestinal barrier permeability by controlling tight junctions, cell polarity, and F-actin dynamics through a ROCK-dependent mechanism.