Inflammatory bowel disease risk gene C1ORF106 regulates actin dynamics in intestinal epithelial cells
Isabelle Hébert-Milette, Chloé Lévesque, Jean Paquette, Marie-Ève Rivard, Louis Robert Villeneuve, Gabrielle Boucher, Philippe Goyette, Guy Charron, John David Rioux
This study shows that C1ORF106 and its IBD variant regulate intestinal barrier permeability by controlling tight junctions, cell polarity, and F-actin dynamics through a ROCK-dependent mechanism.
bioRxiv · Mar 14, 2025 · PreprintGenetics