Geert Poelmans

This paper investigates the shared genetic architecture of psychiatric and insulin resistance conditions using multivariate GWAS and identifies potential biological mechanisms and drug candidates.

This study shows KCNQ1 regulates human neuronal development by affecting cell adhesion, mitochondrial function, and insulin signalling pathways.

The paper investigates the relationship between glutamate and GABA gene-sets, autism symptoms, and cortical thickness using data from the EU-AIMS LEAP cohort.

The paper uses whole exome sequencing in multi-incident families to identify rare genetic variants associated with multiple sclerosis, finding 12 candidate genes involved in myelination and auto-immunity.

This study investigates the association between genetic variation in glutamate and GABA genes and brain structure/chemistry in autism, finding differential involvement in specific brain regions.

The paper investigates genetic overlaps between neuropsychiatric disorders and insulin-related diseases, finding significant genetic correlations and suggesting potential clusters of disorders with divergent pleiotropic effects.

This paper conducts a GWAS on nociceptive musculoskeletal pain treatment response in UK Biobank, identifying one genome-wide significant SNP and suggesting genetic correlations with chronic pain and socioeconomic traits.

This study shows that ACC hypofunction in mice leads to anti-social aggression, with chemogenetic activation of ACC reducing this behavior.

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

This paper introduces quantitative genetic scoring (QGS) to create quantitative genetic variables from arbitrary regions, showing it can reduce genetic data by >98% while explaining phenotypic variance across different granularities.

The paper identifies shared genetic risk factors between OCD, population-based OCS, and insulin signaling traits, suggesting a common etiological mechanism.

This study identifies dopaminergic signaling as a genetic link between ADHD and obesity through genome-wide analyses and brain volume associations.

This study identifies genetic variants associated with sociability as a continuous trait and finds genetic correlations with schizophrenia, major depressive disorder, and autism spectrum disorders.

This study investigates whether social and non-social autism symptom domains are genetically distinct by analyzing genetic correlations between systemizing and autism traits.

This study shows that disrupting the ANK3 gene in mice affects microtubule dynamics via GSK3/CRMP2 signaling, linking it to psychiatric illness mechanisms.