Heterogeneous subpopulations of GABAAR-responding neurons coexist in physiological and pathological mature neuronal networks at increasing scales of complexity
Ilaria Colombi, M. Rastogi, Martina Parrini, M. Alberti, Michela Chiappalone, Marina Nanni, Andrea Contestabile, Laura Cancedda
The paper shows that adult mice and human neurons have heterogeneous GABAergic responses, with DS mice showing higher depolarizing responses and behavioral rescue upon normalization.
bioRxiv · May 25, 2023 · PreprintNeuroscience