Engineered muscle tissues with enhanced maturation enable the identification of clinically relevant rAAV capsids
Clémence Lièvre, Bérangère Robert, Giada Mainieri, Nicolas Jaulin, Marine Cotinat, Christian Mandrycky, David L. Mack, Oumeya Adjali, Caroline Le Guiner, Bodvael Fraysse, Jean-Baptiste Dupont
This study uses engineered human muscle tissues to evaluate AAV capsid efficiency, finding that more mature tissues show improved transduction by AAV9 and MyoAAV variants.
bioRxiv · Jan 14, 2026 · PreprintBioengineering