Oumeya Adjali

This study shows that intracellular accumulation of AAV6 genomes in microglia drives reactivity and inflammation in retinal gene therapy.

This paper introduces an ultrafast method for cell membrane modification using diazonium salts, enabling efficient and safe functionalization of various cell types for biomedical applications.

This study uses engineered human muscle tissues to evaluate AAV capsid efficiency, finding that more mature tissues show improved transduction by AAV9 and MyoAAV variants.

The paper identifies a dynamic gene regulatory network in Duchenne muscular dystrophy that controls cell fate decisions and shows how disease mutations disrupt this network.

This study enhances liver gene therapy by conjugating GalNAc to rAAV capsids, improving transduction efficiency in mice while reducing required dosages.

This study shows that dystrophin deficiency disrupts cell junction formation during embryonic myogenesis in human pluripotent stem cells.

The paper assesses T cell immunity to various AAV serotypes in healthy donors, finding AAV9 has the highest prevalence of pre-existing cellular immunity.