Loss of Kmt2c/d promotes gastric cancer initiation and confers vulnerability to mTORC1 inhibition and anti-PD1 immunotherapy
Naitao Wang, Dan Li, Tao� Zhang, Mohini R. Pachai, Woo Hyun Cho, Makhzuna N. Khudoynazarova, Dana M. Schoeps, Yudi Bao, Marion Liu, Laura H. Tang, Yelena Yuriy Janjigian, Ping Chi, Yu Chen
This study shows that loss of Kmt2c/d promotes gastric cancer initiation and makes tumors sensitive to mTORC1 inhibitors and anti-PD1 immunotherapy.
bioRxiv · Mar 27, 2025 · PreprintCancer Biology