Mohini R. Pachai

This study shows MYC drives endothelial transformation and dedifferentiation in angiosarcoma by promoting lineage plasticity and cell growth.

This study shows that PRC2 inactivation promotes MPNST by reprogramming Schwann-lineage cells and presents a mouse model that recapitulates human PRC2-loss MPNST.

This study identifies BET inhibitors as effective against GI transcriptome-positive CRPC by targeting HNF1A and HNF4G, improving outcomes in preclinical models.

This study shows that loss of Kmt2c/d promotes gastric cancer initiation and makes tumors sensitive to mTORC1 inhibitors and anti-PD1 immunotherapy.