Cyclic uremia without kidney injury drives cardiovascular disease with rapid onset of immunosenescence and heart failure
Gideon J L Schaefer, Patrick Droste, Carla Sophie Schikarski, Xinhui Li, Marius Kohl, Niklas Lutterbach, Henriëtte de Loor, Lars Koch, Sylvia Menzel, Ling Zhang, Qingqing Long, Kristian Vogt, Anne-Sophie Andries, Anne Babler, David Schumacher, , Konrad Hoeft
This study establishes a mouse model of cyclic uremia without kidney injury, showing it drives cardiovascular disease and immunosenescence independently of traditional risk factors.
bioRxiv · Sep 30, 2026 · PreprintSystems Biology