Author

Patrick Droste

Universitätsklinikum AachenORCID 0000-0001-9809-695XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

Peter BooriD· 2 shared Andreas HoeftiD· 1 shared Anne BableriD· 1 shared Anne-Sophie Andries· 1 shared Axel Honne· 1 shared Barbara M. KlinkhammeriD· 1 shared Burcu Yesilyurt Öztürk· 1 shared Carla Sophie Schikarski· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

Peter BoorORCID

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2 papers

Recent·Most cited

Cyclic uremia without kidney injury drives cardiovascular disease with rapid onset of immunosenescence and heart failure

Gideon J L Schaefer, Patrick Droste, Carla Sophie Schikarski, Xinhui Li, Marius Kohl, Niklas Lutterbach, Henriëtte de Loor, Lars Koch, Sylvia Menzel, Ling Zhang, Qingqing Long, Kristian Vogt, Anne-Sophie Andries, Anne Babler, David Schumacher, , Konrad Hoeft

This study establishes a mouse model of cyclic uremia without kidney injury, showing it drives cardiovascular disease and immunosenescence independently of traditional risk factors.

bioRxiv · Sep 30, 2026 · PreprintSystems Biology

The role of Platelet-derived growth factor (PDGF) in uremic vascular calcification.

Burcu Yesilyurt Öztürk, Li Zhang, Saskia Freifrau von Stillfried, Barbara M. Klinkhammer, Julia Möllmann, Patrick Droste, Eva Miriam Buhl, Mathias Hohl, Heidi Noels, Vera Jankowski, Joachim Jankowski, Claudia Goettsch, Nikolaus Marx, Lorin E. Olson, Jürgen Floege, , Peter Boor

This study investigates the role of PDGFR-{beta} in uremic vascular calcification using ex vivo and in vivo models, showing that PDGFR-{beta} activation promotes calcification and VSMC phenotypic switching.

bioRxiv · Jul 9, 2025 · PreprintSystems Biology