Reconstitution of human fetal ovaries reveals niche requirements for primordial germ cell-like cell progression
Yolanda W. Chang, Marjolein Trimp, Talia van der Helm, Albert Blanch-Asensio, Arend W. Overeem, Susana M. Chuva de Sousa Lopes
This study shows that human primordial germ cell-like cells can mature in reconstituted human fetal ovaries and amnion-like cell aggregates, with SCF being crucial for hPGCLC survival.
bioRxiv · Mar 21, 2025 · PreprintDevelopmental Biology