Enhancing Lipid Detection and Spatial Accuracy in Carotid Plaques Using Mass Spectrometry Imaging Techniques
Sphamandla Ntshangase, Sean McCafferty, Zahra Javid, Beth Whittington, Phyo H. Khaing, Tony Feng, Allison C. Winarski, Fraser Simpson, Shazia Khan, Joanna P. Simpson, Hannah O'Neill, Sharon Yen Ming Chan, Ala Hassouneh, Mark Davis, Rahul Velineni, , Ruth Andrew
This study improves MALDI-MSI sample preparation for carotid plaque lipid analysis by comparing methods, finding Cryofilm with sublimation best balances tissue preservation and lipid detection.
bioRxiv · Jan 14, 2026 · PreprintMolecular Biology