Ruth Andrew

Rapid turnover of corticosterone in humans: the role of a second glucocorticoid hormone

This study investigates corticosterone metabolism and dynamics in humans, finding it has faster turnover, greater metabolism, and a stronger ACTH response compared to cortisol.

Localisation of corticosteroids in male mouse kidney by mass spectrometry imaging

This study uses mass spectrometry imaging to map corticosteroid distribution in mouse kidneys, revealing regional localization patterns and dietary salt effects on corticosterone levels.

Enhancing Lipid Detection and Spatial Accuracy in Carotid Plaques Using Mass Spectrometry Imaging Techniques

This study improves MALDI-MSI sample preparation for carotid plaque lipid analysis by comparing methods, finding Cryofilm with sublimation best balances tissue preservation and lipid detection.

Pharmacological inhibition of 11βhydroxysteroid dehydrogenase type 1 after myocardial infarction targets extracellular matrix processing and preserves cardiac function in a translational mini-pig model

This study shows that inhibiting 11βHSD1 after myocardial infarction preserves cardiac function and prevents adverse remodelling in a mini-pig model.

Gene networks driven by genetic variation for plasma cortisol in hepatic and adipose tissues implicate corticosteroid binding globulin in modulating tissue glucocorticoid action and cardiovascular risk

The paper identifies genetic variants associated with plasma cortisol and cardiovascular disease, revealing gene networks in liver and adipose tissues regulated by corticosteroid binding globulin and the glucocorticoid receptor.