Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163
Ching-Shin Huang, Hui Wang, Joshua B. R. White, Oksana Degtjarik, Cindy Huynh, Kristoffer Brännström, Mark T. Horn, Stephen P. Muench, William S. Somers, Javier F. Chaparro‐Riggers, Laura Lin, Lidia Mosyak
This study determines the cryo-EM structures of CD163 in complex with haptoglobin-hemoglobin, revealing its trimeric structure and calcium-dependent mechanism for HpHb clearance.
PLoS Biology · Jul 11, 2025Peer-reviewedBiophysics