Author

Oksana Degtjarik

University of LeedsORCID 0000-0002-1492-9481Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Antonio N. CalabreseiD· 1 shared Arindam DattaiD· 1 shared Ching-Shin HuangiD· 1 shared Cindy Huynh· 1 shared Elton ZeqirajiD· 1 shared Francesca ChandleriD· 1 shared Gemma C. Wildsmith· 1 shared Hirunika Perera· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

Antonio N. CalabreseORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex

Martina Foglizzo, Arindam Datta, Oksana Degtjarik, Hirunika Perera, Jordan Liburd, Upasana M. Sykora, Sri Ranjani Ganji, Gemma C. Wildsmith, Francesca Chandler, Lisa J. Campbell, Antonio N. Calabrese, Roger A. Greenberg, Elton Zeqiraj

The paper investigates how the BRCA1-A complex recognizes and cleaves K63-linked polyubiquitin chains, revealing structural and functional mechanisms involved in DNA damage response.

Nature Communications · Aug 11, 2026Peer-reviewedBiochemistry

Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163

Ching-Shin Huang, Hui Wang, Joshua B. R. White, Oksana Degtjarik, Cindy Huynh, Kristoffer Brännström, Mark T. Horn, Stephen P. Muench, William S. Somers, Javier F. Chaparro‐Riggers, Laura Lin, Lidia Mosyak

This study determines the cryo-EM structures of CD163 in complex with haptoglobin-hemoglobin, revealing its trimeric structure and calcium-dependent mechanism for HpHb clearance.

PLoS Biology · Jul 11, 2025Peer-reviewedBiophysics